Studies show that cannabidiol (CBD) has the capacity to successfully help a lot of individuals. Yet other researches also suggest CBD oil interacts with the endocannabinoid system in a manner that yields quite a handful of unintentional side-effects.

Although most of the scientific research suggests CBD oil is harmless for use and intake, it does present a couple of risks that, if not correctly understood, might be unsafe.

CBD may interact with other drugs that, like itself, are metabolized in the body by the cytochrome p450 enzymes CYP3A4 and CYP2C19. By competing for these enzymes, CBD may minimize the metabolic process of this sort of medications, increasing their blood levels and potentially needing downward modification of their dosages. This has been found in clinical trials in which hundreds of milligrams of CBD are provided everyday. The impact can be less noticeable with CBD supplements which offer smaller dosages (single or tens of milligrams).

CBD has the potential to interact with any medication metabolized by cytochrome P-450 enzymes.  Indiana University Department of Medicine listed below medications known to use the cytochrome P-450 system as follows:

HMG CoA reductase inhibitors


Calcium channel blockers

Prokinetics HIV antivirals


Immune modulators



Macrolide Antibiotics



Antidepressants (SSRIs, SNRIs, MAOIs).

Beta blockers.


Proton-Pump Inhibitors (PPIs).

Angiotension II blockers.

NSAIDs (ibuprofen).

Oral hypoglycemic agents.

Estrogen Modulators (Tamoxifen).


Blood Thinners (Warfarin).

PDE-5 Inhibitors.

Sedatives (Clobazam).

Remember that the list above doesn’t have every drug that might interact with or could be impacted by the CBD oil.  In case you are concerned that your P-450 enzyme system may not be working properly,  consult your physicians.

A case in point: Medications Which Have An Effect On Blood Sugar Levels.

Remarkably, there is proof to indicate cannabis can lower insulin resistance, boost the metabolic process, and strengthen blood sugar control. Nevertheless, many studies evaluate overall patterns, including the causes and effects of different health conditions within particular populations. (A number of research discovered that cannabis users had lower rates of weight problems and diabetic issues when compared to non-users). Nevertheless, limited research particularly observed at how THC, CBD, or other cannabinoids interact with other medications that have known impacts on blood sugar (such as insulin).

While we do not have definitive evidence, it’s likely cannabis may interact with other medications favorably. Yet, by a similar token, there might be a risk that cannabis mixed with other medications might reduce sugar levels excessively. Precisely, patients must constantly keep track of the effects (under medical guidance) to alleviate prospective risks and adjust prescription accordingly.

Another similarly severe potential aspect could be brought on by combining CBD with chemotherapy drugs. The basic principle of this cluster of medications is based on the fact that their daily dose lays only below the toxicity limit. The outcomes of their extended presence in the bloodstream– something that could be, certainly, brought on by CBD– are serious: the toxicity degree can be surpassed, and the medication will quickly end up being a poison!

The Grapefruit Test: A Simple CBD-Drug Interaction Reference.

You probably have heard that doctors usually advise their patients not to eat grapefruit prior to taking many medicines. This is due to the fact that many of the compounds in grapefruit likewise suppress the cytochrome P450 system similar to CBD does. CBD, nevertheless, ends up a more potent inhibitor than compounds in grapefruit such as bergapten (the greatest of many grapefruit elements that hinder this system).

To make things simple, the grapefruit test is an exceptional reference point for CBD interactions. In case your physician has advised you regarding using grapefruit with most of your medicines, it is a powerful indication that you might find similar referrals for CBD oil.